منابع مشابه
Human airway trypsin-like protease increases mucin gene expression in airway epithelial cells.
Human airway trypsin-like protease (HAT) is a serine protease found in sputum of patients with chronic airway diseases and is an agonist of protease-activated receptor-2 (PAR-2). Results from this study show that HAT treatment also enhances mucus production by the airway epithelial cell line NCI-H292 in vitro. Histologic examination showed that HAT enhances mucous glycoconjugate synthesis, wher...
متن کاملRegulation of Tumor Necrosis Factor-α-induced Airway Mucin Production and Gene Expression by Carbenoxolone, Prunetin, and Silibinin
DOI: 10.4046/trd.2010.69.5.348 ISSN: 1738-3536(Print)/2005-6184(Online) Tuberc Respir Dis 2010;69:348-353 CopyrightC2010. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved. Regulation of Tumor Necrosis Factor-α-induced Airway Mucin Production and Gene Expression by Carbenoxolone, Prunetin, and Silibinin Hyun Jae Lee, M.S.*, Su Yel Lee, B.S.*, Byeong Kyou Jeon, Ph....
متن کاملThe effects of herbal plants on Mucin 2 gene expression and performance in ascetic broilers
The mucus layer plays an important role as an intermediate for the protection of the gut against acidic chyme, digestive enzymes, and pathogens; in addition, it acts as a lubricant and facilitator of nutrient transportation. Phytogenic compounds seem to promote intestinal mucus production. OBJECTIVES: The current study was conducted to investigate the effects of low and high levels of energy an...
متن کاملAirway goblet cell mucin: its structure and regulation of secretion.
Mucociliary clearance is a major function of the airway epithelium. This important function depends both on the physicochemical properties of the airway mucus and on the activity of the cilia. The former, in turn, is dependent mainly on the quality and quantity of mucous glycoproteins or mucins, which are produced by two different cell types, namely, goblet cells of the epithelium and mucous ce...
متن کاملRegulation of mucin genes in chronic inflammatory airway diseases.
In this review, we summarize work over the past 15 years on mucin gene expression and regulation in the lung, as well as how mucin gene expression is altered in chronic lung diseases. This field owes a great debt to Carol Basbaum for her pioneering work in dissecting signaling pathways regulating mucin gene expression and for her tremendous energy in promoting the importance of understanding th...
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ژورنال
عنوان ژورنال: Annual Review of Physiology
سال: 2008
ISSN: 0066-4278,1545-1585
DOI: 10.1146/annurev.physiol.70.113006.100441